Seven students were taken into questioning at Nelson Mandela University (NMU) in Port Elizabeth on Tuesday.
Protesting students began Monday morning blocking the entrances to the two campuses in protest of registration issues.
Police spokeswoman Priscilla Naidu says the seven students were taken in for questioning, but only four were arrested for infrastructure damage under the Criminal Procedure Amendment Act and the disregard for a court interdict.
In addition to the demonstration at the entrances, classes were disrupted and staff members intimidated as protesters entered several classrooms.
They are dissatisfied because students with outstanding debt cannot register.
Mbabela said the students who disrupted classes on Tuesday were not part of Monday afternoon’s discussions between the university management and the student council. Several issues regarding registration and financing were resolved during these discussions.